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CasNo: 7793-38-6
MF: C23H29FO6
General Description |
9-Fluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate, also known as Fludrocortisone acetate, is a synthetic corticosteroid with powerful mineralocorticoid properties and some glucocorticoid activity. Corticosteroids are hormones that substantially affect metabolism and immune responses. The mineralocorticoid properties of this chemical compound are responsible for the regulation of salt and water balance in the body. It is primarily used in medicine to treat conditions like Addison's disease, adrenogenital syndrome, and conditions resulting in low levels of sodium in the blood. Its potential side effects may include high blood pressure, a high sodium level, low potassium level, water retention, and issues with the heart and blood vessels. |
InChI:InChI=1/C23H29FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h6,8,10,16-18,27,29H,4-5,7,9,11-12H2,1-3H3/t16-,17-,18?,20-,21-,22-,23-/m0/s1
21-Acetoxy-9α-fluor-11β.17α-dihydroxy-pregna-1,4-dien-3,20-dion
Conditions | Yield |
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Acetat VI: 1) Br2 2) Diphenylhydrazin (I);
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Acetat VI: 1) HBr/Eg. 2) Collidin (II);
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1ξ,21-Diacetoxy-9α-fluor-11β,17α-dihydroxy-pregn-4-en-3,20-dion + Eg.
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21-Acetoxy-9.11-epoxy-17α-hydroxy-pregna-1.4-dien-3.20-dion, HF, CHCl3;
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9α-Fluor-prednisolon-acetat-(17) in Me., wenig methanol. KOH (1percentig)
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9α-Fluor-prednisolon-acetat-(17), p-TsOH, Bzl., Δ;
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21-Acetoxy-9α-fluor-11β.17α-dihydroxy-3.20-dioxo-pregn-4-en, HIO4, Dioxan/Eg.;
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21-Acetoxy-9α-fluor-11β.17α-dihydroxy-pregna-1,4-dien-3,20-dion
Conditions | Yield |
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Hydrierung;
Product distribution;
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21-Acetoxy-9α-fluor-11β.17α-dihydroxy-pregna-1,4-dien-3,20-dion