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CasNo： 160982-09-2
MF： C13H11ClOS2
A large scale synthesis of the topical c...
Compounds of the following formula are d...
Sulfonamides and pharmaceutical composit...
A process for synthesizing carbonic anhy...
3-acetyl-2,5-dichlorothiophene
benzyl chloride
3-Acetyl-2-(phenylmethyl)thio-5-chlorothiophene
| Conditions | Yield |
|---|---|
|
benzyl chloride;
With
thiourea;
In
ethanol; water;
for 2h;
Reflux;
Large scale;
3-acetyl-2,5-dichlorothiophene;
With
sodium hydroxide;
In
ethanol; water;
for 3h;
regioselective reaction;
Reflux;
Large scale;
|
97% |
|
With
sodium hydroxide; sodium hypochlorite; thiourea;
In
ethanol; water;
|
3-acetyl-2,5-dichlorothiophene
benzyl bromide
3-Acetyl-2-(phenylmethyl)thio-5-chlorothiophene
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide; thiourea;
In
tetrahydrofuran; water;
|
88% |
|
With
sodium hydroxide; thiourea;
In
tetrahydrofuran; water;
|
88% |
3-acetyl-2,5-dichlorothiophene
benzyl bromide
benzyl chloride
3-Acetyl-5-chloro-N-[4-(2-hydroxyethyl)phenyl]-thiophene-2-sulfonamide
3-acetyl-5-chloro-2-thiophenesulfonamide
3-Acetyl-5-chloro-N-(4-methoxyphenyl)thiophene-2-sulfonamide
brinzolamide
