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  • Product NameHydrocortisone-17-butyrate
  • CasNo. 13609-67-1
  • MFC25H36O6
  • MW432.557
  • Purity
  • Appearance
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Product Details

CasNo： 13609-67-1

MF： C25H36O6

Manufacturer supply good quality Hydrocortisone-17-butyrate 13609-67-1 with stock

  • Molecular Formula:C25H36O6
  • Molecular Weight:432.557
  • Vapor Pressure:3.76E-16mmHg at 25°C 
  • Melting Point:210.0 to 214.0 °C 
  • Refractive Index:1.564 
  • Boiling Point:585.6 °C at 760 mmHg 
  • PKA:12.98±0.10(Predicted) 
  • Flash Point:194 °C 
  • PSA：100.90000 
  • Density:1.23 g/cm3 
  • LogP:3.13260 

Hydrocortisone-17-butyrate(Cas 13609-67-1) Usage

Biochem/physiol Actions

Hydrocortisone 17-butyrate is a corticosteroid that acts as a dermocorticoid due to its application in dermatological therapy. It exhibits therapeutic effects against vitiligo of the face and neck.

Contact allergens

Hydrocortisone 17-butyrate is a C 17 ester of hydrocorti- sone. It represents the D2 group of corticosteroids, non C 16 methylated with a C 17 ester: hydrocortisone 17-butyrate, hydrocortisone 17-valerate, hydrocortisone aceponate (17-propionate and 21-acetate), methylpred- nisolone aceponate, and prednicarbate. It is sometimes hydrolyzed in vivo into hydrocortisone, giving allergic reactions to group-A-sensitized people.

Definition

ChEBI: Cortisol esterified with butyric acid at the 17-hydroxy group.

Brand name

Locoid (Ferndale); Locoid (Yamanouchi).

InChI:InChI=1/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18?,19-,22?,23-,24-,25-/m0/s1

13609-67-1 Relevant articles

An improved synthesis of corticosteroid 17α-esters by synthetic aluminium silicate-mediated conversion of 17α, 21-cyclic ortho esters

Sugai,Okazaki,Akaboshi

, p. 700 - 701 (1984)

-

Development of a specific radioimmunoassay for cortisol 17-butyrate

Smith,Lee,Bu Lock,et al.

, p. 23 - 36 (1983)

-

Composition for the topical treatment of poison ivy and other forms of contact dermatitis

-

, (2008/06/13)

Composition for topical administration c...

Novel hydrocortisone derivative

-

, (2008/06/13)

17α-butyryloxy-11β-hydroxy-21-propionylo...

13609-67-1 Process route

HYDROCORTISONE
50-23-7

HYDROCORTISONE

1,1,1-trimethoxybutane
43083-12-1

1,1,1-trimethoxybutane

hydrocortisone 17α-butyrate
13609-67-1

hydrocortisone 17α-butyrate

21-oxobutoxy-11β,17α-dihydroxypregn-4-ene-3,20-dione
6677-99-2

21-oxobutoxy-11β,17α-dihydroxypregn-4-ene-3,20-dione

Conditions
Conditions Yield
With hydrogenchloride; toluene-4-sulfonic acid; Yield given. Multistep reaction. Yields of byproduct given; 1) acetonitrile, 13 min, 2) acetonitrile, 14 min;
Hydrocortisone 17α,21-ethyl orthobutanoate
49757-02-0

Hydrocortisone 17α,21-ethyl orthobutanoate

hydrocortisone 17α-butyrate
13609-67-1

hydrocortisone 17α-butyrate

Conditions
Conditions Yield
aluminium silicate; In methanol; water; for 1h; Heating;
78%

13609-67-1 Upstream products

  • 50-23-7
    50-23-7

    HYDROCORTISONE

  • 43083-12-1
    43083-12-1

    1,1,1-trimethoxybutane

  • 49757-02-0
    49757-02-0

    Hydrocortisone 17α,21-ethyl orthobutanoate

13609-67-1 Downstream products

  • 72590-77-3
    72590-77-3

    hydrocortisone butyrate propionate

  • 50-23-7
    50-23-7

    HYDROCORTISONE

  • 6677-99-2
    6677-99-2

    21-oxobutoxy-11β,17α-dihydroxypregn-4-ene-3,20-dione

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