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CasNo： 881386-01-2
MF： C11H10Cl2N2O3
Factory Sells Best Quality 3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone 881386-01-2 with ISO standards We supply high quality 2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)- (CAS 881386-01-2), in stock, factory directly supply to clients, lower prices, more competitiveness.
2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)- is , while it's Molecular Formula is C11H10Cl2N2O3. Used in Pharmaceutical Industry:
2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)is used as a key intermediate in the production of apixaban derivatives. These derivatives are valuable in the development of anticoagulant medications, specifically targeting Factor Xa to prevent blood clot formation. 2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-'s unique binding properties to Factor Xa make it an essential component in the synthesis of apixaban-based drugs, which have potential applications in the treatment and prevention of various thrombotic disorders.
The CAS number of 2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)- is 881386-01-2.
More information of 2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)- 881386-01-2 are:
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Synonyms |
3,3-dichloro-1-(4-nitrophenyl)-2-piperidinone;QC-8280;2-Piperidinone,3,3-dichloro-1-(4-nitrophenyl); |
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CAS Number |
881386-01-2 |
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Molecular Formula |
C11H10Cl2N2O3 |
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Molecular Weight |
289.118 |
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Density |
1.50 |
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Boiling Point |
520.2±50.0 °C(Predicted) |
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PSA |
66.13000 |
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LogP |
3.48370 |
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Pka |
-7.38±0.40(Predicted) |
3, 3-dichloro-1 -(4-nitrophenyl) -2-piperidinone is an important pharmaceutical intermediate, as it can be used to prepare apixaban derivatives. Apixaban is a small molecular selective FXa inhibitor of pyrazole derivatives. Similar to Rivaroxaban, apixaban has two binding sites to Factor Xa, where 4-methoxyphenyl in the apixaban structure partially binds the S1 pocket of Factor Xa and aryllactam partially binds the S4 pocket of Factor Xa.
Articles related to 2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-:
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Article |
Source |
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Preparation method of apixaban intermediate suitable for industrial production |
- , (2021/08/19) |
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Design, synthesis, and biological activity of novel tetrahydropyrazolopyridone derivatives as FXa inhibitors with potent anticoagulant activity |
Sun, Xiaoqing,Hong, Zexin,Liu, Moyi,Guo, Su,Yang, Di,Wang, Yong,Lan, Tian,Gao, Linyu,Qi, Hongxia,Gong, Ping,Liu, Yajing , p. 2800 - 2810 (2017/04/18) |
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