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CasNo： 1262780-97-1
MF： C38H73N21O10S2
The present invention relates to an impr...
The present invention provides a method ...
The instant disclosure is directed to so...
S-trityl-L-cysteine
Ac-D-Cys(Trt)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2 tetrahydrochloride
etelcalcetide
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride; iodine;
In
methanol; water;
pH=1.85;
|
90% |
Fmoc-D-Cys (Mtt)-OH
N-α-tert-butoxycarbonyl-S-(3-nitro-2-pyridylthio)-L-cysteine
acetic anhydride
N-(9-fluorenylmethoxycarbonyl)-D-alanine
N-α-[(9H-fluoren-9-ylmethoxy)carbonyl]-NG-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine
etelcalcetide
| Conditions | Yield |
|---|---|
|
N-α-[(9H-fluoren-9-ylmethoxy)carbonyl]-NG-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine;
With
4-(2,4-dimethoxyphenyl-Fmoc-aminomethyl)phenoxy resin; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
1-methyl-pyrrolidin-2-one;
at 20 ℃;
for 5h;
rink amide resin
With
piperidine;
In
1-methyl-pyrrolidin-2-one;
rink amide resin
Fmoc-D-Cys (Mtt)-OH; N-α-tert-butoxycarbonyl-S-(3-nitro-2-pyridylthio)-L-cysteine; acetic anhydride; N-(9-fluorenylmethoxycarbonyl)-D-alanine; N-α-[(9H-fluoren-9-ylmethoxy)carbonyl]-NG-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine;
Further stages;
|
60% |
l-cysteine hydrochloride
S-trityl-L-cysteine
