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  • Product Name4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
  • CasNo. 1050477-27-4
  • MF
  • MW378.431
  • Purity
  • Appearance
  • Packing
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Product Details

CasNo： 1050477-27-4

Factory Sells Best Quality 4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide 1050477-27-4 with stock

  • Molecular Formula:C21H22N4O3
  • Molecular Weight:378.431
  • Vapor Pressure:0Pa at 25℃ 
  • Boiling Point:554.7±50.0 °C(Predicted) 
  • PKA:14.76±0.40(Predicted) 
  • Density:1.29±0.1 g/cm3(Predicted) 

1050477-27-4 Relevant articles

Enantioselective Total Synthesis of (?)-Finerenone Using Asymmetric Transfer Hydrogenation

Aggarwal, Varinder K.,Farrar, Elliot H. E.,Gandhamsetty, Narasimhulu,Grayson, Matthew N.,Lerchen, Andreas,Platzek, Johannes,Winter, Nils

, p. 23107 - 23111 (2020)

(?)-Finerenone is a nonsteroidal mineral...

METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOXAMIDE AND RECOVERY OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOXAMIDE BY ELECTROCHEMICAL METHODS

-

, (2018/09/16)

The present invention relates to a novel...

METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOXAMIDE AND THE PURIFICATION THEREOF FOR USE AS AN ACTIVE PHARMACEUTICAL INGREDIENT

-

Paragraph 0201-0206, (2018/09/16)

The present invention relates to a novel...

METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOX-AMIDE AND THE PURIFICATION THEREOF FOR USE AS AN ACTIVE PHARMACEUTICAL INGREDIENT

-

Paragraph 0179-0183, (2017/08/26)

The present invention relates to a novel...

1050477-27-4 Process route

4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid
1050477-45-6

4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid

4(R,S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
1050477-27-4

4(R,S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide

Conditions
Conditions Yield
4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid; With 1,1'-carbonyldiimidazole; In ethyl acetate; at 20 ℃;
With ammonium hydroxide; at 100 ℃; for 0.5h;
96%
4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid; With dmap; 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 - 50 ℃; for 3.5h; Large scale;
With 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; for 22h; Reflux; Large scale;
94%
Multi-step reaction with 3 steps
1: dmap / tetrahydrofuran / 3.5 h / 20 - 50 °C / Large scale
2: tetrahydrofuran / 22 h / Reflux; Large scale
3: water / tetrahydrofuran / 4 h / 5 °C / Reflux; Large scale
With dmap; water; In tetrahydrofuran;
4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxamide

4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxamide

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

4(R,S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
1050477-27-4

4(R,S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide

Conditions
Conditions Yield
With sulfuric acid; In N,N-dimethyl acetamide; at 50 - 115 ℃; for 1.5h; Large scale;
92%

1050477-27-4 Upstream products

  • 1050477-45-6
    1050477-45-6

    4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid

  • 530-62-1
    530-62-1

    1,1'-carbonyldiimidazole

  • 4421-08-3
    4421-08-3

    3-methoxy-4-hydroxybenzonitrile

  • 652997-57-4
    652997-57-4

    3-methoxy-4-O-trifluoromethylsulfonylbenzonitrile

1050477-27-4 Downstream products

  • 1050477-31-0
    1050477-31-0

    BAY948862

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