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CasNo： 98717-15-8
MF： C17H27ClN2O
|
Definition |
ChEBI: The anhydrous form of (S)-ropivacaine hydrochloride. |
InChI:InChI=1/C17H26N2O.ClH/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H
The preparation method comprises the fol...
The invention discloses an industrial sy...
The invention discloses a preparation me...
The invention discloses a process for en...
ropovacaine tartarate
ropivacaine hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
water; isopropyl alcohol;
at 60 - 65 ℃;
for 2h;
Solvent;
Temperature;
|
84.78% |
ropivacaine
ropivacaine hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
4-methyl-2-pentanone; isopropyl alcohol;
at 20 - 40 ℃;
for 1.75 - 2.75h;
Product distribution / selectivity;
|
98.9% |
|
With
hydrogenchloride;
In
water; acetone;
at 25 - 60 ℃;
|
87% |
|
With
hydrogenchloride;
In
water;
for 2.5h;
pH=3.6 - 3.7;
Product distribution / selectivity;
|
|
|
With
hydrogenchloride; pyrographite;
In
water;
at 70 - 80 ℃;
for 0.5h;
pH=3 - 3.5;
|
> 99.85 % ee |
|
With
hydrogenchloride;
In
water; isopropyl alcohol;
at 40 ℃;
for 0.8h;
pH=1 - 2;
pH-value;
Wavelength;
Sonication;
|
|
|
With
hydrogenchloride;
In
water; isopropyl alcohol;
at 50 ℃;
for 2h;
|
76 g |
(+/-)-2',6'-pipecoloxylidide hydrochloride
propyl bromide
ropivacaine
propyl (1-propylpiperidine)-2-carboxylate
ropivacaine
ropivacaine hydrochloride monohydrate
