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  • Product Nametert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate
  • CasNo. 1201187-44-1
  • MF
  • MW388.447
  • Purity
  • Appearance
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Product Details

CasNo： 1201187-44-1

Manufacturer Sells Best Quality tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate 1201187-44-1 with stock

  • Molecular Formula:C18H20N4O4S
  • Molecular Weight:388.447
  • PKA:9.45±0.43(Predicted) 
  • Density:1.35±0.1 g/cm3(Predicted) 

1201187-44-1 Relevant articles

IRAK4 kinase inhibitor and preparation method thereof

-

Paragraph 0115-0117; 0121-0123; 0152-0154; 0158-0160; 0187, (2021/02/05)

The present invention provides a compoun...

Development of a Scalable Enantioselective Synthesis of JAK Inhibitor Upadacitinib

Bhagavatula, Lakshmi,Christesen, Alan,Dunn, Travis B.,Ickes, Andrew,Kotecki, Brian J.,Marek, James C.,Morrill, Westin H.,Moschetta, Eric,Mulhern, Mathew,Rasmussen, Michael,Reynolds, Troy,Rozema, Michael J.,Yu, Su

, (2021/10/21)

Process development of a six-stage synth...

Influenza virus replication inhibitors and uses thereof (by machine translation)

-

Paragraph 0415; 0423-0424, (2019/10/01)

The invention provides a compound as an ...

Synthesis method of JAK (Janus Kinase) inhibitor

-

Paragraph 0083-0084, (2019/03/08)

The invention discloses a synthesis meth...

1201187-44-1 Process route

tert-butyl carbazate
4248-19-5

tert-butyl carbazate

2-bromo-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine
1201186-54-0

2-bromo-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine

N-(5-(p-toluenesulfonyl)pyrrolo[2,3-b]pyrazin-2-yl)carbamic acid tert-butyl ester
1201187-44-1

N-(5-(p-toluenesulfonyl)pyrrolo[2,3-b]pyrazin-2-yl)carbamic acid tert-butyl ester

Conditions
Conditions Yield
With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 105 ℃; for 2.5h;
75%
With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 105 ℃; for 2.5h; Inert atmosphere;
75%
With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; tert-Amyl alcohol; at 95 ℃; for 3h;
74%
With C36H26OP2*Pd(2+)*2C2H3O2(1-); caesium carbonate; In 1,4-dioxane; at 100 ℃; for 15h; Inert atmosphere;
71%
With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 95 ℃; for 18h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;
51.2%
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; tert-butyl XPhos; In 1,4-dioxane; at 90 ℃;
With pyridine; at 50 ℃; for 2h; Temperature;
With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 95 ℃; for 2h; Inert atmosphere; Large scale;
5-tosyl-5H-pyrrolo[2,3-b]pyrazine-2-carboxylic acid

5-tosyl-5H-pyrrolo[2,3-b]pyrazine-2-carboxylic acid

<i>tert</i>-butyl alcohol
75-65-0

tert-butyl alcohol

N-(5-(p-toluenesulfonyl)pyrrolo[2,3-b]pyrazin-2-yl)carbamic acid tert-butyl ester
1201187-44-1

N-(5-(p-toluenesulfonyl)pyrrolo[2,3-b]pyrazin-2-yl)carbamic acid tert-butyl ester

Conditions
Conditions Yield
With diphenylphosphoranyl azide; triethylamine; at 70 ℃; for 16h;
54%

1201187-44-1 Upstream products

  • 4248-19-5
    4248-19-5

    tert-butyl carbazate

  • 1201186-54-0
    1201186-54-0

    2-bromo-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine

  • 875781-41-2
    875781-41-2

    5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

  • 75-65-0
    75-65-0

    tert-butyl alcohol

1201187-44-1 Downstream products

  • 1201186-08-4
    1201186-08-4

    8-cyclohexyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

  • 1201187-52-1
    1201187-52-1

    8-cyclohexyl-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

  • 1421338-21-7
    1421338-21-7

    C21H24N4O3S

  • 1201187-46-3
    1201187-46-3

    2-amino-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine

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