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CasNo： 87864-14-0
MF： C16H20 Cl N3 O
InChI:InChI=1/C16H20ClN3O/c1-3-20(4-2)10-9-18-16(21)13-11-15(17)19-14-8-6-5-7-12(13)14/h5-8,11H,3-4,9-10H2,1-2H3,(H,18,21)
This invention is in the field of medici...
Enterovirus A71 (EV-A71) is a human path...
The invention discloses a quinoline form...
The invention discloses a method for pre...
2-chloroquinoline-4-carbonyl chloride
N,N-diethylethylenediamine
2-chloro-quinoline-4-carboxylic acid-(2-diethylamino-ethylamide)
| Conditions | Yield |
|---|---|
|
N,N-diethylethylenediamine;
With
triethylamine;
In
dichloromethane;
for 0.25h;
Cooling with ice;
2-chloroquinoline-4-carbonyl chloride;
In
dichloromethane;
at 20 ℃;
Cooling with ice;
|
94% |
|
With
chloroform; benzene;
|
|
|
With
sodium carbonate; benzene;
|
|
|
With
benzene;
|
|
|
With
triethylamine;
In
dichloromethane;
at 15 - 20 ℃;
for 1.5h;
|
153.6 g |
|
With
triethylamine;
In
dichloromethane;
|
2-chloroquinoline-4-carboxylic acid
N,N-diethylethylenediamine
2-chloro-quinoline-4-carboxylic acid-(2-diethylamino-ethylamide)
| Conditions | Yield |
|---|---|
|
With
N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
N,N-dimethyl-formamide;
at 20 ℃;
|
82% |
|
2-chloroquinoline-4-carboxylic acid;
With
N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
N,N-dimethyl-formamide;
for 0.0333333h;
Inert atmosphere;
N,N-diethylethylenediamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
Inert atmosphere;
|
82% |
2-chloroquinoline-4-carbonyl chloride
N,N-diethylethylenediamine
2-hydroxyquinoline-4-carboxylic acid
2-chloroquinoline-4-carboxylic acid
Dibucaine
N-[2-(diethylamino)ethyl]-2-ethoxyquinoline-4-carboxamide
2-(2-methoxy-ethoxy)-quinoline-4-carboxylic acid-(2-diethylamino-ethylamide)
N-[2-(diethylamino)ethyl]-2-(2-ethoxyethoxy)quinoline-4-carboxamide
