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  • Product NameMethyl 3 - (benzyl) - 1 - ((TERT butoxycarbonyl) amino) - 4-oxo-1,4-dihydropyridine-2-carboxylate
  • CasNo. 518048-02-7
  • MFC24H25FN4O5
  • MW468.48
  • Purity
  • Appearanceoff-white solid
  • Packing
  • Contact usInquiry

Product Details

CasNo： 518048-02-7

MF： C24H25FN4O5

Appearance： off-white solid

Quality manufacturer supply Methyl 3 - (benzyl) - 1 - ((TERT butoxycarbonyl) amino) - 4-oxo-1,4-dihydropyridine-2-carboxylate 518048-02-7 in stock with high standard

  • Molecular Formula:C24H25FN4O5
  • Molecular Weight:468.48
  • Appearance/Colour:off-white solid 
  • Melting Point:167-170 °C 
  • Refractive Index:1.602 
  • PKA:4.50±1.00(Predicted) 
  • PSA：122.55000 
  • Density:1.304 g/cm3 
  • LogP:3.49830 

BENZYL [1-[4-[[(4-FLUOROBENZYL)AMINO]CARBONYL]-5-HYDROXY-1-METHYL-6-OXO-1,6-DIHYDROPYRIMIDIN-2-YL]-1-METHYLETHYL]CARBAMATE(Cas 518048-02-7) Usage

InChI:InChI=1/C24H25FN4O5/c1-24(2,28-23(33)34-14-16-7-5-4-6-8-16)22-27-18(19(30)21(32)29(22)3)20(31)26-13-15-9-11-17(25)12-10-15/h4-12,30H,13-14H2,1-3H3,(H,26,31)(H,28,33)

518048-02-7 Relevant articles

(Chloromethyl)dimethylchlorosilane-KF: A Two-Step Solution to the Selectivity Problem in the Methylation of a Pyrimidone Intermediate en Route to Raltegravir

Stathakis, Christos I.,Gkizis, Petros L.,Alexandraki, Elli S.,Trakossas, Sakellarios,Terzidis, Michael,Neokosmidis, Efstratios,Zacharis, Constantinos K.,Vasiliadou, Christina,Vastardi, Elli,Andreou, Thanos,Zitrou, Asteria,Varvogli, Anastasia-Aikaterini,Koftis, Theocharis V.

, p. 1413 - 1418 (2017)

The present work describes a two-step pr...

A newfangled synthesis of integrase inhibitor drug substance raltegravir potassium

Rao, S. Venkat,Potluri, Vamsi Krishna,Potluri, Ramesh Babu

, p. 2618 - 2622 (2019/10/02)

Raltegravir sodium synthesis was achieve...

PROCESS FOR PREPARING COMPOUNDS USEFUL AS INTERMEDIATES FOR THE PREPARATION OF RALTEGRAVIR

-

Page/Page column 23-24, (2018/04/11)

The invention discloses a novel and sele...

Identification, synthesis, and strategy for minimization of potential impurities observed in raltegravir potassium drug substance

Patil, Gulabrao D.,Kshirsagar, Siddheshwar W.,Shinde, Shivnath B.,Patil, Pankaj S.,Deshpande, Mangesh S.,Chaudhari, Ashok T.,Sonawane, Swapnil P.,Maikap, Golak C.,Gurjar, Mukund K.

, p. 1422 - 1429 (2012/10/29)

Multiple sources of anticipated degradat...

518048-02-7 Process route

2-(1-benzyloxycarbonylamino-1-methyl-ethyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid methyl ester
888504-27-6

2-(1-benzyloxycarbonylamino-1-methyl-ethyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid methyl ester

para-fluorobenzylamine
140-75-0

para-fluorobenzylamine

{1-[4-(4-fluoro-benzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl]-1-methyl-ethyl}carbamic acid benzyl ester
518048-02-7

{1-[4-(4-fluoro-benzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl]-1-methyl-ethyl}carbamic acid benzyl ester

Conditions
Conditions Yield
In ethanol; at 4 - 72 ℃; for 4h;
90%
2-(1-benzyloxycarbonylamino-1-methyl-ethyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid methyl ester; para-fluorobenzylamine; In ethanol; at 4 - 72 ℃; for 5h;
In ethanol; water; at 60 ℃;
90%
In ethanol; at 4 - 72 ℃; for 4h;
90%
In ethanol; at 4 - 72 ℃; for 4h;
90%
In ethanol; at 4 - 72 ℃; for 4.75h;
90%
In ethanol; at 0 - 72 ℃; for 4.25h; Large scale reaction;
90%
In methanol; at 60 - 65 ℃;
2-(1-benzyloxycarbonylamino-1-methyl-ethyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid methyl ester; para-fluorobenzylamine; In ethanol; for 3h; Reflux;
With acetic acid; In ethanol; water;
13.2 g
{1-[4-(4-fluoro-benzylcarbamoyl)-5,6-dihydroxy-pyrimidin-2-yl]-1-methyl-ethyl}-carbamic acid benzyl ester
519028-33-2

{1-[4-(4-fluoro-benzylcarbamoyl)-5,6-dihydroxy-pyrimidin-2-yl]-1-methyl-ethyl}-carbamic acid benzyl ester

trimethylsulfoxonium iodide
1774-47-6

trimethylsulfoxonium iodide

{1-[4-(4-fluoro-benzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl]-1-methyl-ethyl}carbamic acid benzyl ester
518048-02-7

{1-[4-(4-fluoro-benzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl]-1-methyl-ethyl}carbamic acid benzyl ester

Conditions
Conditions Yield
With magnesium hydroxide; In 1-methyl-pyrrolidin-2-one; water; at 97 - 109 ℃; for 6.5h;
89%
With magnesium hydroxide; In water; at 100 ℃;
89%

518048-02-7 Upstream products

  • 888504-27-6
    888504-27-6

    2-(1-benzyloxycarbonylamino-1-methyl-ethyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid methyl ester

  • 140-75-0
    140-75-0

    para-fluorobenzylamine

  • 519028-33-2
    519028-33-2

    {1-[4-(4-fluoro-benzylcarbamoyl)-5,6-dihydroxy-pyrimidin-2-yl]-1-methyl-ethyl}-carbamic acid benzyl ester

  • 1774-47-6
    1774-47-6

    trimethylsulfoxonium iodide

518048-02-7 Downstream products

  • 1193687-88-5
    1193687-88-5

    ethyl (2-(4-(4-fluorobenzylcarbamoyl)-1,6-dihydro-5-hydroxy-1-methyl-6-oxopyrimidin-2-yl)propan-2-ylcarbamoyl)formate

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