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CasNo： 906673-45-8
MF： C14H10BrNO2
The invention discloses a preparation me...
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4-(4-bromo-3-formaldehydephenoxy)benzonitrile
4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile
| Conditions | Yield |
|---|---|
|
With
sodium tetrahydroborate;
In
methanol;
at 20 ℃;
for 1h;
|
100% |
|
With
methanol; sodium tetrahydroborate;
at 10 - 30 ℃;
Temperature;
|
99% |
|
With
methanol; sodium tetrahydroborate;
at 25 ℃;
for 4h;
|
92% |
|
With
methanol; sodium tetrahydroborate;
at 25 ℃;
for 2h;
|
92% |
|
With
sodium tetrahydroborate; water; sodium hydroxide;
In
methanol;
at 0 ℃;
for 1h;
Inert atmosphere;
|
80% |
|
4-(4-bromo-3-formaldehydephenoxy)benzonitrile;
With
sodium tetrahydroborate;
In
methanol;
at 20 ℃;
for 1h;
With
water;
|
|
|
4-(4-bromo-3-formaldehydephenoxy)benzonitrile;
With
sodium tetrahydroborate;
In
methanol;
at 20 ℃;
for 1h;
With
water;
In
methanol;
|
(2-bromo-5-hydroxybenzene)methanol
4-fluorobenzonitrile
4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile
| Conditions | Yield |
|---|---|
|
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 80 - 90 ℃;
|
96.2% |
|
With
potassium carbonate;
In
dimethyl sulfoxide;
at 125 ℃;
for 4h;
Inert atmosphere;
|
54% |
4-(4-bromo-3-formaldehydephenoxy)benzonitrile
2-bromo-5-hydroxybenzaldehyde
4-fluorobenzonitrile
(2-bromo-5-hydroxybenzene)methanol
C19H18BrNO3
AN2728
