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CasNo： 312307-38-3
MF： C11H7FN2O
The invention discloses a synthetic meth...
The invention relates to substituted pyr...
The present invention provides a kind of...
The invention relates to a novel pyrrole...
2'-Fluoroacetophenone
malononitrile
![2-[2-(2-fluorophenyl)-2-oxoethyl]propanedinitrile](/upload/2025/4/34d3f49a-ab4d-44ac-889b-033624c4e90e.png)
2-[2-(2-fluorophenyl)-2-oxoethyl]propanedinitrile
| Conditions | Yield |
|---|---|
|
2'-Fluoroacetophenone;
With
hydrogen bromide; dihydrogen peroxide; ethyl acetate;
In
water;
at 25 ℃;
for 3h;
malononitrile;
With
triethylamine;
at 0 - 5 ℃;
for 1.5h;
Temperature;
|
80.5% |
|
2'-Fluoroacetophenone;
With
bromine;
In
ethyl acetate;
at 20 ℃;
for 2h;
malononitrile;
With
triethylamine;
In
ethyl acetate;
at 0 - 5 ℃;
for 3h;
|
67.8% |
2'-Fluoroacetophenone
2-[2-(2-fluorophenyl)-2-oxoethyl]propanedinitrile
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1: copper(I) bromide / ethyl acetate / 80 °C
2: potassium hydroxide / ethanol; water / 2 h / 20 °C
With
potassium hydroxide; copper(I) bromide;
In
ethanol; water; ethyl acetate;
|
|
|
Multi-step reaction with 2 steps
1: tetra-N-butylammonium tribromide / tetrahydrofuran / 20 - 30 °C
2: sodium carbonate / ethyl acetate / 5 h / 35 °C
With
tetra-N-butylammonium tribromide; sodium carbonate;
In
tetrahydrofuran; ethyl acetate;
|
2'-Fluoroacetophenone
malononitrile
S-{3-cyano-5-(2-fluorophenyl)-1H-pyrrol-2-yl}benzenecarbothioate
1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-yl]-N-methylmethylamine fumaric acid salt
5‐(2-fluorophenyl)‐1‐(pyridine-3-sulfonyl)-1H-pyrrole-3-carbaldehyde
5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde
