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CasNo： 79794-75-5
MF： C22H23ClN2O2
Appearance： white crystalline solid
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Loratadine is white crystalline solid, while it's Molecular Formula is C22H23ClN2O2. Loratadine, is used as a peripheral histamine H1 receptor agonist. It is also used as an orally active antiallergic agent. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff.
The CAS number of Loratadine is 79794-75-5.
More information of Loratadine 79794-75-5 are:
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Synonyms |
Sch 29851;Bedix Loratadina;Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate;Claratyne;Biloina;Histaloran;Lorastine;Alarin;Loratadine (JAN/USAN);Loratadina [Spanish];Loradif;Claritin D;Sensibit;Loranox;1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester;Sohotin;Clarityne;Fristamin;Bonalerg;Aerotina;Claritin;Rhinase;Alerpriv;Lertamine;Allertidin;Loratadine (79794-75-5);Loratadina;Clarityne-D;Lorantis;Pylor;Lowadina;Lesidas;Loratyne;Tadine; |
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CAS Number |
79794-75-5 |
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Molecular Formula |
C22H23ClN2O2 |
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Molecular Weight |
382.89 |
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Density |
1.261 g/cm3 |
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Melting Point |
134-136 ºC |
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Boiling Point |
531.3 ºC at 760 mmHg |
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Flash Point |
275.1 ºC |
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HS CODE |
DERIVATION |
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PSA |
42.43000 |
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LogP |
4.82570 |
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Pka |
4.27±0.20(Predicted) |
Loratadine is a non-sedating antihistamine indicated for use in allergic rhinitis and chronic urticaria. Its major advantage over other non-sedating antihistamines such as astemizole and terfenadine is its very fast onset of action. Loratadine is claimed not to cross the blood-brain barrier.
InChI:InChI=1/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
Articles related to Loratadine:
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Article |
Source |
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Preparation method of loratadine |
- Paragraph 0029; 0058-0064, (2021/02/10) |
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NEW PROCESS FOR PREPARING LORATADINE FROM A KETONE INTERMEDIATE |
- Page/Page column 9, (2015/06/18) |
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