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CasNo: 343306-79-6
MF: C72H104Na8O48S8
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Sugammadex Sodium is the first in a class of drugs called selective relaxant binding agents that offers improved termination of the paralytic effects of neuromuscular blocking agents and may have many potential peri-operative benefits.
The CAS number of Sugammadex sodium is 343306-79-6.
More information of Sugammadex sodium 343306-79-6 are:
|
CAS Number |
343306-79-6 |
|
Density |
1.275g/cm3 (calc.) |
|
PSA |
994.80000 |
|
LogP |
-18.35920 |
Synonyms for Sugammadex sodium 343306-79-6:Org 25969;Sugammadex sodium;Bridion;
The chemical formula of Sugammadex sodium is C72H104Na8O48S8 which containing 72 Carbon atoms,104 Hydrogen atoms,8 Sodium atoms,48 Oxygen atoms and 8 Sulfur atoms,and the molecular weight of Sugammadex sodium is 2178.03328 .
To facilitate tracheal intubation, mechanical ventilation, and surgical access, NMB agents are frequently used as non-anesthetic adjuncts in surgical procedures. Sugammadex is able to function as a pharmacologic sink of rocuronium and vecuronium, another non-depolarizing neuromuscular blocker, without the cardiovascular adverse effects experienced with reversal agents that directly interact with the cholinergic system. The γ-cyclodextrin has been designed to enhance binding of the guest by incorporating acidic side chains to promote an electrostatic interaction with the positive nitrogen of the blocker. Starting with γ-cyclodextrin, these side chains are readily installed by first halogenating with iodine or bromine to provide a handle for nucleophilic displacement with either 3-mercaptopropionic acid in the presence of sodium hydride or with 3-mercaptopropionic acid methyl ester and cesium carbonate. The latter requires hydrolysis with sodium hydroxide to generate sugammadex sodium.
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