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CasNo： 57-91-0
MF： C18H24O2
Appearance： White solid
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Biological Activity |
Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively). |
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Biochem/physiol Actions |
Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke. |
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Purification Methods |
17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o. |
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Definition |
ChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer). |
InChI:InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
Zr-containing MOF-808 is a very promisin...
The invention belongs to the technical f...
Various defect-engineered Zr-trimesate M...
The synthesis of 17α-hydroxy steroids ge...
Estrone
estradiol
α-estradiol
| Conditions | Yield |
|---|---|
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With
ethanol; nickel;
at 120 ℃;
under 14710.2 Torr;
Hydrogenation;
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With
potassium hydroxide; aluminum nickel;
at 80 - 90 ℃;
|
|
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With
aluminum isopropoxide; isopropyl alcohol;
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|
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With
<(+)-(2R,3R)-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane (diop)>Rh(solvent)Cl; diphenylsilane;
In
xylene;
at 22 ℃;
Product distribution;
|
|
|
With
diphenylsilane;
(-)DIOP-Rh;
In
xylene;
at 75 ℃;
for 2h;
Mechanism;
Product distribution;
also at 5 degC, other time , also (+)DIOP-Rh, other solvent;
|
|
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Estrone;
In
2-methyltetrahydrofuran;
Inert atmosphere;
Reflux;
With
aluminum tri-sec-butoxide;
In
2-methyltetrahydrofuran;
for 18h;
Inert atmosphere;
Reflux;
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23.5 g |
|
With
isopropyl alcohol;
at 80 ℃;
for 24h;
Reagent/catalyst;
Time;
chemoselective reaction;
Catalytic behavior;
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24 % de |
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With
Zr-containing metal-organic framework-808;
In
iso-butanol;
at 119.84 ℃;
for 8h;
Solvent;
Reagent/catalyst;
diastereoselective reaction;
|
74 % de |
|
With
aluminum isopropoxide;
In
iso-butanol;
at 119.84 ℃;
for 24h;
Reagent/catalyst;
|
32 % de |
estrone p-toluenesulfonylhydrazone
estradiol
α-estradiol
| Conditions | Yield |
|---|---|
|
With
sodium tetrahydroborate;
In
water; isopropyl alcohol;
for 16h;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
Ambient temperature;
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1,3,5-trinitrobenzene
Estrone
pentan-1-ol
17α-dihydroequilenin
17β-oestradiol diacetate
17-β-estradiol 17-acetate
17α-estradiol-3-amidosulfonate
3β-D-glucopyranosyl-17α-estradiol
