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CasNo： 10040-45-6
MF： C18H13NNa2O8S2
Appearance： gray powder complex
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Therapeutic Function |
Laxative |
InChI:InChI=1/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2
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Guttalax
| Conditions | Yield |
|---|---|
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Dinatrium-p,p'-picolyliden-(2)-bis-(o,o'-dibrom-phenylsulfat), Ni-Al/NaOH (-Red.) (Ausb.62percent);
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Dinatrium-p,p'-picolyliden-(2)-bis-(o-chlor-phenylsulfat), Ni-Al/NaOH (-Red.) (Ausb.68percent);
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Picolyliden-(2)-bis-phenol, 1. Chlorsulfonsaeure/Py., 2. NaOH (Ausb.65percent);
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Dinatrium-p,p'-picolyliden-(2)-bis-(o-brom-phenylsulfat), Ni-Al/NaOH (-Red.) (Ausb.70percent);
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Dinatrium-p,p'-picolyliden-(2)-bis-(o,o'-dichlor-phenylsulfat), Ni-Al/NaOH (-Red.) (Ausb.55percent);
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4,4'-(2-pyridylmethylene)diphenol
Guttalax
| Conditions | Yield |
|---|---|
|
4,4'-(2-pyridylmethylene)diphenol;
With
pyridine; chlorosulfonic acid;
at 0 - 20 ℃;
for 5h;
With
sodium hydroxide;
Concentration;
Cooling with ice;
|
86.4% |
|
4,4'-(2-pyridylmethylene)diphenol;
With
morpholine; pyridine; aminosulfonic acid;
In
1-methyl-pyrrolidin-2-one;
at 40 - 50 ℃;
for 12h;
With
sodium ethanolate;
In
methanol;
at 40 - 50 ℃;
for 1h;
Reagent/catalyst;
|
71.2% |
|
4,4'-(2-pyridylmethylene)diphenol;
With
pyridine; chlorosulfonic acid;
at 35 - 40 ℃;
for 3h;
Flow reactor;
With
sodium hydroxide;
|
59.9% |
|
4,4'-(2-pyridylmethylene)diphenol;
With
pyridine; chlorosulfonic acid;
at 10 - 25 ℃;
for 12h;
Inert atmosphere;
Large scale;
With
water; sodium hydroxide;
at 0 ℃;
pH=11;
pH-value;
Inert atmosphere;
Large scale;
|
2.1 kg |
4,4'-(2-pyridylmethylene)diphenol
1-bromo-4-methoxy-benzene
ethyl-2-picolinate
4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate
4,4'-(2-pyridylmethylene)diphenol
