Synthesis

Add 6L of dimethyl sulfoxide and 1kg of succinic anhydride in the reaction kettle, stir and dissolve at 25°C, add 0.8L of triethylamine, and stir for 10 minutes; add 1kg of methylprednisolone again, react at 30°C for 3 hours, add 10% hydrochloric acid water Terminate the reaction, separate 40 L of water, and stir for 30 minutes; filter and wash with water to obtain the crude product; the crude product is dissolved in 30 times of methanol temperature, and activated carbon is decolorized to obtain methylprednisolone succinate; the yield is 119%, and the content is 99.3%.