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CasNo： 31431-39-7
MF： C16H13N3O3
Appearance： white to yellowish powder
Top Quality Chinese Manufacturer supply 31431-39-7 mebendazol We supply high quality Mebendazole (CAS 31431-39-7), in stock, factory directly supply to clients, lower prices, more competitiveness.
Mebendazole is white to yellowish powder, while it's Molecular Formula is C16H13N3O3. For the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.
The CAS number of Mebendazole is 31431-39-7.
More information of Mebendazole 31431-39-7 are:
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Synonyms |
Methyl 5-benzoyl-2-benzimidazolecarbamate;2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester;Sufil;R 17635;Equivurm Plus;MBDZ;Methyl 5-benzoyl benzimidazole-2-carbamate;Versid;(5-Benzoyl-1H-benzimidazol-2-yl)carbamic acid methyl ester;Mebex;Verpanyl;Mebendazole (JAN/USP);2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester (8CI);Mebutar;5-Benzoyl-2-benzimidazolecarbamic acid methyl ester;Telmin;Vermox (TN);R 17,635;Bantenol;Telluryl compoundsTelmin;Vermox;R 17, 635;Lomper;Pantelmin;Methyl 5-benzoyl-2-benzimidazolylcarbamate; |
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CAS Number |
31431-39-7 |
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Molecular Formula |
C16H13N3O3 |
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Molecular Weight |
295.298 |
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Density |
1.388 g/cm3 |
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Melting Point |
288.5 °C |
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Boiling Point |
436.98°C (rough estimate) |
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HS CODE |
29339900 |
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PSA |
84.08000 |
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LogP |
3.04520 |
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Pka |
pKa 3.43/9.93(H2O,t =25,I=0.025) (Uncertain) |
Mebendazole is a broad-spectrum anthelmintic that is active against both larval and adult stages of nematodes selectively binding the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in the parasite (IC50 = 0.19 μM for Giardia in vitro). As a tubulin-binding agent, mebendazole also possesses antitumor properties, inducing apoptosis of various human carcinomas both in vitro and in vivo, thus preventing their growth and migration. Furthermore, mebendazole has been used to inhibit hedgehog signaling in cancer cells via suppression of the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for hedgehog pathway activation. Additionally, mebendazole has been shown to stabilize the transcriptional activator HIF-1α and its downstream targets, abrogating oxidative neuronal death in primary neurons.
InChI:InChI=1/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21)
Articles related to Mebendazole:
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Article |
Source |
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Method for synthesizing mebendazole by means of methyl cyanocarbamate |
- Paragraph 0043-0050, (2019/10/10) |
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MEBENDAZOLE POLYMORPH FOR TREATMENT AND PREVENTION OF TUMORS |
- Sheet 9/17, (2016/09/22) |
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